A man and a woman have died and five people have been injured in a blaze at a house in Manchester.
Four children, aged between 10 and 17, and a man are being treated in hospital after fire crews were called at 02:20 GMT.
The man is in a serious condition, while the conditions of three girls and a boy are not known.
A neighbour said he had heard people at the property in Parsonage Road, Withington screaming for help.
Mike Parr said he called 999 after he was woken by the fire, adding: “There was a huge amount of black smoke coming out of the house, quite a lot of flames.”
Formal identification of the bodies and post-mortem examinations are yet to take place, Greater Manchester Police said.
Officers are investigating the cause of the blaze in conjunction with the fire service.
Det Insp Tony Lea said: “My thoughts are with the family of the man and woman after such a tragic incident and we have specially-trained officers supporting the family at this time.”